Copper-Catalyzed Arylation of Heterocycle C-H Bonds
Hien-Quang Do and Olafs Daugulis J. Am. Chem. Soc., 129 (41), 12404 -12405, 2007
Abstract: A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert-butoxide base, aryl iodide coupling partner, and copper iodide catalyst.